ChloroquineV1, Main, Exploration, bibRecord, 000A89

Anemoside B4 exerts anti-cancer effect by inducing apoptosis and autophagy through inhibiton of PI3K/Akt/mTOR pathway in hepatocellular carcinoma

Identifieur interne : 000A89 ( Main/Exploration ); précédent : 000A88; suivant : 000A90

Anemoside B4 exerts anti-cancer effect by inducing apoptosis and autophagy through inhibiton of PI3K/Akt/mTOR pathway in hepatocellular carcinoma

Source :

American Journal of Translational Research [ 1943-8141 ] ; 2019.

RBID : PMC:6511782

Abstract

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide and novel therapeutic approaches are urgently required. Anemoside B4 (AB4) is a compound extracted from Pulsatilla chinensis (P. chinensis). Previous studies have indicated that P. chinensis extract P. chinensis saponins has anti-cancer activity. However, the pharmacological effect of AB4 in cancer is largely unknown. In this study, we investigated the anti-cancer efficacy of AB4 in HCC. We used CCK-8 assay and colony formation assay to evaluate the cytotoxicity of AB4 and found that this agent markedly inhibited SMMC7721 cell proliferation. By using a panel of morphological and molecular experiments, we reported that AB4 induced HCC SMMC7721 cell apoptosis and autophagy. Notably, AB4 treatment acts on the Bcl-2-caspase-3 pathway and Beclin-1-LC3-p62 pathway, thereby regulates both apoptosis and autophagy. Finally, we showed that AB4-induced apoptosis and autophagy converges at the PI3K/Akt/mTOR signaling. AB4 treatment inhibits this signaling transduction pathway and leads to HCC cell death. Collectively, our study highlighted the anti-cancer efficacy of AB4 and suggested that AB4 might be a novel way to treat HCC.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511782

PubMed: 31105864
PubMed Central: 6511782

Affiliations:

République populaire de Chine

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Anemoside B4 exerts anti-cancer effect by inducing apoptosis and autophagy through inhibiton of PI3K/Akt/mTOR pathway in hepatocellular carcinoma</title>
<author><name sortKey="Xue, Shuyi" sort="Xue, Shuyi" uniqKey="Xue S" first="Shuyi" last="Xue">Shuyi Xue</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Pharmacology, Pharmaceutical College of Qingdao University</institution>
<addr-line>Qingdao 266021, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266021, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhou, Yu" sort="Zhou, Yu" uniqKey="Zhou Y" first="Yu" last="Zhou">Yu Zhou</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au3"><institution>College of Pharmacy, Pharmaceutical College of Dalian Medical University</institution>
<addr-line>Dalian 116000, Liaoning, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Dalian 116000, Liaoning</wicri:regionArea>
<wicri:noRegion>Liaoning</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Jin" sort="Zhang, Jin" uniqKey="Zhang J" first="Jin" last="Zhang">Jin Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="au4"><institution>Department of Hand Surgery, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xiang, Zhuo" sort="Xiang, Zhuo" uniqKey="Xiang Z" first="Zhuo" last="Xiang">Zhuo Xiang</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miao, Ting" sort="Miao, Ting" uniqKey="Miao T" first="Ting" last="Miao">Ting Miao</name>
<affiliation wicri:level="1"><nlm:aff id="au5"><institution>Institute of Integrative Medicine, Qingdao University</institution>
<addr-line>Qingdao 266003, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266003, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Guoxin" sort="Liu, Guoxin" uniqKey="Liu G" first="Guoxin" last="Liu">Guoxin Liu</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Bangguo" sort="Liu, Bangguo" uniqKey="Liu B" first="Bangguo" last="Liu">Bangguo Liu</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Xu" sort="Liu, Xu" uniqKey="Liu X" first="Xu" last="Liu">Xu Liu</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shen, Lixia" sort="Shen, Lixia" uniqKey="Shen L" first="Lixia" last="Shen">Lixia Shen</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Zhe" sort="Zhang, Zhe" uniqKey="Zhang Z" first="Zhe" last="Zhang">Zhe Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Mingchun" sort="Li, Mingchun" uniqKey="Li M" first="Mingchun" last="Li">Mingchun Li</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miao, Qing" sort="Miao, Qing" uniqKey="Miao Q" first="Qing" last="Miao">Qing Miao</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">31105864</idno>
<idno type="pmc">6511782</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511782</idno>
<idno type="RBID">PMC:6511782</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000352</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000352</idno>
<idno type="wicri:Area/Pmc/Curation">000352</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000352</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000A15</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A15</idno>
<idno type="wicri:Area/Ncbi/Merge">000631</idno>
<idno type="wicri:Area/Ncbi/Curation">000631</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000631</idno>
<idno type="wicri:Area/Main/Merge">000A89</idno>
<idno type="wicri:Area/Main/Curation">000A89</idno>
<idno type="wicri:Area/Main/Exploration">000A89</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Anemoside B4 exerts anti-cancer effect by inducing apoptosis and autophagy through inhibiton of PI3K/Akt/mTOR pathway in hepatocellular carcinoma</title>
<author><name sortKey="Xue, Shuyi" sort="Xue, Shuyi" uniqKey="Xue S" first="Shuyi" last="Xue">Shuyi Xue</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Pharmacology, Pharmaceutical College of Qingdao University</institution>
<addr-line>Qingdao 266021, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266021, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhou, Yu" sort="Zhou, Yu" uniqKey="Zhou Y" first="Yu" last="Zhou">Yu Zhou</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au3"><institution>College of Pharmacy, Pharmaceutical College of Dalian Medical University</institution>
<addr-line>Dalian 116000, Liaoning, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Dalian 116000, Liaoning</wicri:regionArea>
<wicri:noRegion>Liaoning</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Jin" sort="Zhang, Jin" uniqKey="Zhang J" first="Jin" last="Zhang">Jin Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="au4"><institution>Department of Hand Surgery, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xiang, Zhuo" sort="Xiang, Zhuo" uniqKey="Xiang Z" first="Zhuo" last="Xiang">Zhuo Xiang</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miao, Ting" sort="Miao, Ting" uniqKey="Miao T" first="Ting" last="Miao">Ting Miao</name>
<affiliation wicri:level="1"><nlm:aff id="au5"><institution>Institute of Integrative Medicine, Qingdao University</institution>
<addr-line>Qingdao 266003, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266003, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Guoxin" sort="Liu, Guoxin" uniqKey="Liu G" first="Guoxin" last="Liu">Guoxin Liu</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Bangguo" sort="Liu, Bangguo" uniqKey="Liu B" first="Bangguo" last="Liu">Bangguo Liu</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Xu" sort="Liu, Xu" uniqKey="Liu X" first="Xu" last="Liu">Xu Liu</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shen, Lixia" sort="Shen, Lixia" uniqKey="Shen L" first="Lixia" last="Shen">Lixia Shen</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Zhe" sort="Zhang, Zhe" uniqKey="Zhang Z" first="Zhe" last="Zhang">Zhe Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Mingchun" sort="Li, Mingchun" uniqKey="Li M" first="Mingchun" last="Li">Mingchun Li</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miao, Qing" sort="Miao, Qing" uniqKey="Miao Q" first="Qing" last="Miao">Qing Miao</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pharmacy, Hospital 971 of The Navy of Chinese PLA</institution>
<addr-line>Qingdao 266071, Shandong, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Qingdao 266071, Shandong</wicri:regionArea>
<wicri:noRegion>Shandong</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">American Journal of Translational Research</title>
<idno type="eISSN">1943-8141</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide and novel therapeutic approaches are urgently required. Anemoside B4 (AB4) is a compound extracted from <italic>Pulsatilla chinensis</italic>
 (<italic>P. chinensis</italic>
). Previous studies have indicated that <italic>P. chinensis</italic>
 extract <italic>P. chinensis</italic>
 saponins has anti-cancer activity. However, the pharmacological effect of AB4 in cancer is largely unknown. In this study, we investigated the anti-cancer efficacy of AB4 in HCC. We used CCK-8 assay and colony formation assay to evaluate the cytotoxicity of AB4 and found that this agent markedly inhibited SMMC7721 cell proliferation. By using a panel of morphological and molecular experiments, we reported that AB4 induced HCC SMMC7721 cell apoptosis and autophagy. Notably, AB4 treatment acts on the Bcl-2-caspase-3 pathway and Beclin-1-LC3-p62 pathway, thereby regulates both apoptosis and autophagy. Finally, we showed that AB4-induced apoptosis and autophagy converges at the PI3K/Akt/mTOR signaling. AB4 treatment inhibits this signaling transduction pathway and leads to HCC cell death. Collectively, our study highlighted the anti-cancer efficacy of AB4 and suggested that AB4 might be a novel way to treat HCC.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Xue, Shuyi" sort="Xue, Shuyi" uniqKey="Xue S" first="Shuyi" last="Xue">Shuyi Xue</name>
</noRegion>
<name sortKey="Li, Mingchun" sort="Li, Mingchun" uniqKey="Li M" first="Mingchun" last="Li">Mingchun Li</name>
<name sortKey="Liu, Bangguo" sort="Liu, Bangguo" uniqKey="Liu B" first="Bangguo" last="Liu">Bangguo Liu</name>
<name sortKey="Liu, Guoxin" sort="Liu, Guoxin" uniqKey="Liu G" first="Guoxin" last="Liu">Guoxin Liu</name>
<name sortKey="Liu, Xu" sort="Liu, Xu" uniqKey="Liu X" first="Xu" last="Liu">Xu Liu</name>
<name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name>
<name sortKey="Miao, Qing" sort="Miao, Qing" uniqKey="Miao Q" first="Qing" last="Miao">Qing Miao</name>
<name sortKey="Miao, Ting" sort="Miao, Ting" uniqKey="Miao T" first="Ting" last="Miao">Ting Miao</name>
<name sortKey="Shen, Lixia" sort="Shen, Lixia" uniqKey="Shen L" first="Lixia" last="Shen">Lixia Shen</name>
<name sortKey="Xiang, Zhuo" sort="Xiang, Zhuo" uniqKey="Xiang Z" first="Zhuo" last="Xiang">Zhuo Xiang</name>
<name sortKey="Xue, Shuyi" sort="Xue, Shuyi" uniqKey="Xue S" first="Shuyi" last="Xue">Shuyi Xue</name>
<name sortKey="Zhang, Jin" sort="Zhang, Jin" uniqKey="Zhang J" first="Jin" last="Zhang">Jin Zhang</name>
<name sortKey="Zhang, Zhe" sort="Zhang, Zhe" uniqKey="Zhang Z" first="Zhe" last="Zhang">Zhe Zhang</name>
<name sortKey="Zhou, Yu" sort="Zhou, Yu" uniqKey="Zhou Y" first="Yu" last="Zhou">Yu Zhou</name>
<name sortKey="Zhou, Yu" sort="Zhou, Yu" uniqKey="Zhou Y" first="Yu" last="Zhou">Yu Zhou</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A89 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A89 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:6511782
   |texte=   Anemoside B4 exerts anti-cancer effect by inducing apoptosis and autophagy through inhibiton of PI3K/Akt/mTOR pathway in hepatocellular carcinoma
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:31105864" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ChloroquineV1

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

Serveur d'exploration Chloroquine

Anemoside B4 exerts anti-cancer effect by inducing apoptosis and autophagy through inhibiton of PI3K/Akt/mTOR pathway in hepatocellular carcinoma

Anemoside B4 exerts anti-cancer effect by inducing apoptosis and autophagy through inhibiton of PI3K/Akt/mTOR pathway in hepatocellular carcinoma

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.